In a rare and extreme case, a 37-year-old woman in California injected black widow spider venom directly into her bloodstream. She was rushed to the hospital with severe muscle cramps, headaches, anxiety, and trouble breathing. The woman crushed a black widow spider and mixed it with distilled water before injecting it. Her symptoms started an hour later. At the hospital, she had a fast heartbeat, high blood pressure, and mild fever. Hours after admission, her breathing worsened, and she was moved to intensive care. The woman had asthma, which doctors believed made her condition worse due to an allergic reaction to the venom’s proteins. Medical team treated her with intravenous calcium gluconate and morphine for pain. They also tried asthma medicines like albuterol and steroids to ease her breathing. Antivenin was avoided because it might have caused dangerous allergic reactions. By the second day, her breathing returned to normal, muscle pain eased, and she was moved to a general ward. She left the hospital the next day with advice to continue asthma medicines and oral steroids. Most black widow spider bites happen by accident, with about 2,600 reported annually in the U.S. The woman’s deliberate venom injection made this case unusual, as injecting venom directly can cause much stronger effects than normal spider bites. Doctors warn that this can be very risky, especially for people with breathing problems like asthma.